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Codon Optimisation

For years, Big Pharma has had its eye on mRNA gene transfer technology. In 2019 a Milken Institute panel specifically discussed how they might achieve the transition from conventional vaccine development to novel mRNA technology. A year into the roll-out of the Covid vaccines we’re realising that scientists’ understanding of them is sadly lacking.


The Covid vaccines do not contain the identical mRNA found in the SARS-CoV-2 virus: the mRNA has been genetically manipulated in a process called codon optimisation. This process is now known to create completely unforeseen side effects (such as neuro-degenerative diseases and heart failure) as it can result in protein 'misfolding'. Trying to tell your body to generate proteins is hard for many reasons. One of them is the fact that when you try to run the protein information via ribosomes which process that code and generate the protein, the process can either be very slow or malfunction. Luckily, scientists found a way to overcome this problem by doing code substitution. Instead of using the original genetic code to generate the protein they changed the letters in the code so that the code would be optimised – ie: codon optimisation.


Pfizer appears to have been the most aggressive in their codon optimisation. In its Risk Management Plan submitted to the Food and Drugs Administration (FDA) in the US, Pfizer admits that the codon optimisation they did resulted in elevated gamma-glutamyl transferase (GGT) which is an early marker of heart failure. Participants included Dr. Anthony Fauci – Director of the National Institutes of Allergy and Infectious Diseases – and Rick Bright Ph.D., former Director of the US Biomedical Advanced Research and Development Authority and now a senior Vice President of Pandemic Prevention and Response at The Rockefeller Foundation. Bright suggested: “There may be a need, even an urgent call, for an entity of excitement which is completely disruptive; not beholden to bureaucratic strings and processes.” Reading between the lines, it sounds as though he was suggesting that a pandemic could help them make this risky transition, as circumventing bureaucratic strings and processes would likely be more acceptable in the face of an acute crisis.


Bright and Fauci got their wish and the global population is paying the price for their decision to throw bureaucratic strings and processes to the wind, along with the precautionary principle. Many doctors and scientists warned that mRNA-based vaccines were ill advised and premature. In an August 2021 article British cyber-security researcher Ehden Biber reviewed how the mRNA vaccines were made, focusing on what he believes may be the worst design flaw in human history. Here’s an excerpt from his eye-opening article: “Codons are three nucleotides which are the building blocks of our DNA. Here is an example of Codon Optimisation: 60% of the codons were altered. 22% of the nucleotides were altered. Yet the end result is that the ribosomes generate the same protein. Same? Well, no actually.” In 2011 Nature Medicine magazine published an article called 'Breaking the Silence'. It described how codon optimisation, which uses these synonymous DNA changes, can trigger disease in a number of ways. “The protein manufactured during codon optimisation has different ways it folds and a different 3D shape, and it could cause immuno-genicity which wouldn’t be seen until late-stage clinical trials or even after approval. This statement relates to the NORMAL approval cycle: the Covid vaccines went via an ACCELERATED one.”


It’s no secret that the heavy alteration of the mRNA may cause protein misfolding and 'splicing anomalies'. As noted in a March 2021 paper, the BNT162b2 vaccine against Covid-19 is composed of an RNA having 4284 nucleotides, divided into six sections, which provide information to create a factory of S spike proteins to infect the host – the ones used by SARS-CoV-2. After that, these proteins are directed outside the cell, triggering the immune reaction and antibody production. The problem is the heavy alteration of the mRNA. Uracil is replaced with pseudo-uridine to fool the immune system, the letters of all codon triplets are replaced by a C or a G to increase the speed of protein synthesis, while some amino acids are replaced with proline. In addition, the mRNA injected is pre-mRNA, which can lead to multiple mature mRNAs. These are alternative splicing anomalies, a direct source of serious long-term harm to human health.


Pfizer admits that the codon optimisation they did resulted in elevated GGT which, as well as being an early indicator of heart failure is also an indicator of insulin resistance, cardio-metabolic disease, liver disease and chronic kidney disease. When your GGT is elevated, it also means your liver is under stress. The ideal level of GGT is below 16 units per litre for men and below 9 units per litre for women. Above 25 units for men and 18 units for women, the risk of chronic disease increases significantly. What’s more, as your GGT level rises, your glutathione goes down. This is part of the equation explaining how elevated GGT harms your health, but despite the fact that Pfizer acknowledges these risks they did not conduct studies to assess pharmacological safety. Under normal circumstances these are carried out during animal studies. No animal studies were done for the Covid vaccines, hence none were performed – period! Thanks to the fast-tracking the mRNA vaccines went straight into human trials, and it’s just astounding that they rolled out these vaccines to billions of people worldwide knowing full well that they have the ability to cause serious problems. Cell types differ widely in their coder usage, so determining how the mRNA is translated in one type of tissue reveals nothing about the translational kinetics in a different one. None of the Covid vaccine manufacturers have tested their product on all of the tissue types available – 51 in all: they modified the genetic code of their RNA to ensure that the resulting spike protein that your body makes would be more stable, and to bypass protective mechanisms in the cells that prevent viral replication. Without this change, your immune system would simply destroy the mRNA before your cells could start producing spike protein.


If one wanted to create a vaccine one would not target the part of the virus that is most prone to mutation (the spike protein) – one would select a part of the virus that is less likely to mutate. By targeting the spike protein, pharmaceutical companies set themselves up to produce multiple vaccines to keep up with mutations, so choosing the spike protein has been a financial decision. Moreover, by selecting the spike protein as the target they chose to programme your body to produce the most toxic portion of the virus. We know that the spike protein alone is pathogenic – producing blood clots and abnormal bleeding – even without the rest of the virus. Clotting and haemorrhaging is due to the fact that your immune system will attack and destroy the cells inside your vascular system that produce spike protein.


Many experts are now admitting the pandemic is over, but the pandemic industrial complex is not willing to let go of its golden goose. As discussed in the 2019 Milken Institute meeting, they’re in hot pursuit of universal mRNA-based super-shots. In 2019 Dr. Fauci’s focus was a universal influenza vaccine. Today the goal is a universal Covid vaccine to protect against both old and new strains. One way to achieve that could be to target the n-protein located inside the virus rather than the spike protein, as is currently done. By targeting a portion of the virus that doesn’t mutate much from one strain to the next, one might achieve broader protection. Why didn’t they do that from the start?


Big Pharma, national health agencies and political leaders are now relentlessly pushing forward, calling for every man, woman and child to be vaccinated multiple times, but there's no doubt these Covid vaccines are the greatest human experiment in history. The ramifications are already beyond devastating, but we really have no idea as to what the full extent will be. The same can be said for every other pandemic measure employed, from universal masking and social distancing to complete lockdowns. Not one is backed by scientific evidence showing effectiveness, and we’ve only scratched the surface when it comes to assessing the damage they’ve caused.


To subdue dissent against this unethical experimentation on the public an outrageously radical idea – Morality Pills – has been suggested. Drug the population into submission! Widespread administration of psychoactive drugs would provide 'moral enhancement' that would make people more likely to accept social norms such as wearing masks and adhering to social distancing guidelines. This suggestion fits hand in glove with technocratic ideology, which basically states that technocrats – a small, powerful elite who believe they can achieve immortality through transhumanism – are smarter and more worthy of life than everyone else and therefore have the right to dictate moral truth to the masses.

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